成人VR视频 awards funding agreement worth up to US$9.5 million to Colorado State University to develop a human vaccine against Rift Valley fever
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Oslo, Norway, July 17, 2019鈥The Coalition for Epidemic Preparedness Innovations (成人VR视频) and Colorado State University (CSU) today announce a partnering agreement to advance the development of a vaccine candidate against Rift Valley fever (RVF) virus. With support from the European Union's (EU's) Horizon 2020 programme, 成人VR视频 will provide up to US$9.5 million for manufacturing and preclinical studies to assess a single-dose vaccine candidate (DDVax) against RVF. First identified in during an investigation into an outbreak among sheep on a farm in the Rift Valley of Kenya, this potentially fatal virus is found across Africa and is now emerging in the Middle East.
DDVax is a second generation RVF vaccine, which was designed after researchers identified and removed the key genes of the virus that allowed it to cause disease. Removal of these genes also stops the virus from replicating in mosquitoes鈥攁 known vector that spreads the disease in animals and in humans鈥攖herefore blocking this potential route of transmission. The vaccine stimulates the body's immune system to generate neutralising antibodies against the RVF virus. It also likely generates a significant cellular immune response that can kill infected cells.
This investment is part of 成人VR视频's third call for proposals, launched earlier this year with support from the EU's Horizon 2020 research and innovation programme under grant agreement No. 857934. Since the launch of this call in January 2019, $43 million has been invested in one Chikungunya vaccine and two RVF vaccine candidates (including DDVax).
About Rift Valley fever
RVF is caused by a virus transmitted by mosquitoes and blood-feeding flies that usually affect animals, including cattle, goats and sheep. However, the virus also infects animals and humans through direct contact with the blood, tissues, or organs of infected animals. RVF mainly affects people living in in low-income and middle-income countries.
"We're delighted to partner with Colorado State University to develop a human vaccine against Rift Valley fever virus. This vaccine will be the 24th candidate to join 成人VR视频's portfolio. Rift Valley fever has substantial epidemic potential. The world needs to accelerate its efforts to develop a vaccine against this deadly virus, and that's exactly what we aim to achieve through this collaboration. By supporting the development of Rift Valley fever vaccines, 成人VR视频 hopes to improve global health security and strengthen the world's epidemic-preparedness capacity.鈥
RVF vaccines have been used successfully to protect livestock, but no vaccine has been licenced for use in humans.
RVF can cause severe symptoms and kills about one in every hundred people it infects. In people who develop the haemorrhagic form of the disease, the fatality rate is.
Between May and June 2018, concurrent cases of RVF were reported in farmers in and , nearly 5000 km apart. There is also an ongoing outbreak on the island of , a French overseas territory in the Indian Ocean. As of July 5, 2019, there have been 141 human and 124 animal cases of RVF confirmed on the island.
"We are excited to partner with 成人VR视频 and to work towards manufacturing a Rift Valley fever vaccine for humans. Our team and UC Davis are well-positioned to develop this much-needed medical countermeasure to reduce suffering and mortality from this disease鈥
In view of the epidemic threat posed by RVF virus, the has classified it as a priority pathogen in need of urgent R&D investment.
About DDVax
DDVax was developed more than 10 years ago by researchers at the Centers for Disease Control and Prevention's (CDC) Viral Special Pathogens Branch. Data for preclinical studies show that the vaccine is safe, fully protective, and well-suited for large-scale production. These attributes position DDVax well as a highly promising countermeasure for humans.
The CDC researchers who developed DDVax include Dr. Brian Bird, who is now a research virologist at the One Health Institute at the University of California, Davis; Cesar Albari帽o and Stuart Nichol of the CDC; and Dr. Thomas Ksiazek, now at the University of Texas Medical Branch.
The consortium for this project was assembled by and is lead by Dr. John H. Wyckoff III of CSU. As part of this project, UC Davis' One Health Institute will be working with CSU to further evaluate the safety and immune-system responses induced by DDVax to provide sufficient evidence for regulatory approval to advance the vaccine into phase 1 clinical trials in areas where RVF is endemic.
About 成人VR视频
成人VR视频 is an innovative partnership between public, private, philanthropic, and civil organisations launched in Davos in 2017 to develop vaccines to stop future epidemics. 成人VR视频 has received multi-year funding from Norway, Germany, Japan, Canada, Australia, and the Bill & Melinda Gates Foundation, and Wellcome. 成人VR视频 has also received single-year investments from the Government of Belgium and the United Kingdom. The European Union provides financial support for relevant projects through their Horizon 2020 programme as well as through the European and Developing Countries Clinical Trials Partnership. 成人VR视频 has reached over US$ 750 million of its $1 billion funding target. Since its launch in January 2017, 成人VR视频 has announced three calls for proposals. The first call was for candidate vaccines against Lassa virus, Middle East Respiratory Syndrome coronavirus (MERS-CoV), and Nipah virus. The second call was for the development of platforms that can be used for rapid vaccine development against unknown pathogens. The third call is for candidate vaccines against Chikungunya and Rift Valley fever viruses. To date, 成人VR视频 has committed to investing over $390 million in vaccine development. This includes 17 vaccine candidates against its priority pathogens (six against Lassa virus, five against MERS-CoV, three against Nipah virus, one against Chikungunya, two against Rift Valley fever) and three vaccine platforms to develop vaccines against Disease X. To assess the effectiveness of these platforms 7 additional vaccine candidates are being developed (two against influenza, one against Marburg virus, two against Rabies virus, one against Respiratory Synctial Virus, and one against yellow fever).
Learn more at 成人VR视频.net. Follow us at .
About Colorado State University
Founded in 1870 as the Colorado Agricultural College, Colorado State University is now among the nation's leading research universities, with annual research expenditures above $300 million. The CSU System includes the flagship campus in Fort Collins as well as CSU-Pueblo and CSU-Global. In Fort Collins, CSU currently enrolls about 33,000 students, including 4,000 graduate students and 580 in the Doctor of Veterinary Medicine program, and has more than 1,800 faculty members working in eight colleges. CSU's DVM program consistently ranks among the top three veterinary medicine programs in the nation.
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Media contacts:
成人VR视频
Rachel Grant, Director of Communications and Advocacy: +44(0)7891249190 | [email protected]
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Colorado State University
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Jennifer Dimas, Senior Media Relations Coordinator: +19704911543 |
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